A new cholesterol-lowering medication may help a doctor treat a high, according to new research.
The study, by researchers from the British Heart Foundation, was published in the New England Journal of Medicine in early July.
But it's not clear whether the new drug, Crestor, will actually lead to better cholesterol control.
"This study was conducted in healthy volunteers," Dr. David Woodcock, an assistant professor in the division of medicine and cardiovascular and pulmonary medicine at Harvard Medical School, said in a statement.
"This is important because the impact of the drug on cholesterol is already well established and can be considered a potential side effect of this therapy," Woodcock said.
Researchers used data from more than 20,000 patients who took the drug, including a small group of patients who took an additional drug that may be a potential side effect of Crestor.
Other studies have suggested that Crestor may have a more favorable effect on cholesterol than Crestor, Woodcock said.
"The side effects are similar to those associated with Crestor, and the clinical benefit is more clear than we had hoped," he said.
The study was sponsored by the Cleveland Clinic and has helped to shape a range of studies about the benefits of Crestor.
"The results were promising," Woodcock said.
The results were published last year in theJournal of the American Medical Association.
It has not been made public. The researchers said they do not know whether Crestor is the first drug approved for use in adults.
It is not known whether Crestor is safe and effective in children.
The drug is also not FDA-approved for the treatment of high cholesterol, Woodcock said.
"It is a prescription medicine and a prescription drug," he said.
"It is not clear whether it is safe and effective for this use, and if it is safe and effective for the long term use, but it may be safe and effective for short term use."
He added that he does not know whether Crestor is the most effective drug currently on the market.
He added that Crestor does not come with a safety or efficacy end-all; instead, it is designed to treat a condition that is likely to lead to heart attack and stroke.
The study was funded by the British Heart Foundation.
The researchers also reported that the drug has been used off-label for the treatment of high cholesterol.
In the study, a small group of patients took a new cholesterol-lowering drug, Lipitor, and were given a placebo. The researchers then compared the results with those of the group that took Crestor.
"We were able to find that Crestor led to better cholesterol control compared to Crestor. This is the first study to show that Crestor can lead to better cholesterol control," Woodcock said.
The research has important implications for the management of the cardiovascular disease that Crestor is intended to treat. The drug is not approved for the treatment of hypertension, coronary artery disease or type 2 diabetes.
The study was conducted in the Department of Internal Medicine at the University of Michigan School of Medicine.
It was published in the journalJAMA Internal Medicinein early July.
It has helped shape a range of studies about the benefits of Crestor and Crestor, Woodcock said.
Researchers said that the study did not show that Crestor was a side effect of the drug.
"The study was done in healthy volunteers, and the results were very reassuring," Woodcock said.
The researchers said that the results showed that Crestor had a greater effect on lowering LDL cholesterol and a lower risk of heart attack and stroke than on controlling high cholesterol.
"This is the first study to show that Crestor can lead to better cholesterol control," Woodcock said.
The study was sponsored by the Cleveland Clinic and has helped shape a range of studies about the benefits of Crestor and Crestor, Woodcock said.
It was the first trial to examine the effects of Crestor on heart disease.
Crestor is not approved for use in adults.
Highlights
Originally Published: Monday, May 20, 2013 at 12:01 AM PDT
Merck and its new chief executive officer, Tom Merck, will have to pay $60 billion to settle allegations that it improperly marketed Crestor, the generic version of Lipitor, without the necessary approval from a US health regulator.
The $60 billion cash-settlement between the two companies is one of the largest cash-stamp deals in the world, with annual revenue of more than $3.2 billion.
The other cash-stamp deal is AstraZeneca’s new chief executive, Ian Read, who has been accused of overselling the drug’s blockbuster statin Lipitor, saying it was “a major contributor to AstraZeneca’s earnings and a major contributor to revenues of about $2.2 billion”.
The cash-settlement, which will be disclosed as part of the company’s second-tier deal, is one of several deals the company has been trying to make in the past.
Merck has also been negotiating for Crestor, which is approved by the US Food and Drug Administration for its statin drug, in a deal that the company, AstraZeneca, will use to bolster the company’s existing pipeline, including pipeline drugs that are approved by the FDA.
AstraZeneca is also in the process of negotiating for its chief executive officer, Robert Shire, and other key executive positions, as well as the current Chief Financial Officer, John C. Walsh, the company’s chief operating officer.
AstraZeneca is the biggest in the world for the drugs it is developing. It is the second-biggest drugmaker by revenue.
Merck recently announced it would launch the first-ever generic version of Crestor in the United States.
Crestor is a widely prescribed cholesterol-lowering drug used to reduce high cholesterol in people with high triglycerides and bad blood, as well as to prevent heart attacks, cancer, strokes, and some types of arthritis.
Merck is not the only pharmaceutical company to benefit from the cash-settlement.</p
Other companies, including Eli Lilly and Co., have also been working on cash-settlement deals for Crestor.
Other deals are also on the horizon for a potential Crestor acquisition, including a deal to acquire Schering-Plough’s Wyeth for $1.6 billion.
Analysts have suggested that the two companies could be more aggressive in trying to acquire AstraZeneca, a drugmaker that has been battling a patent battle with AstraZeneca over Crestor’s cholesterol-lowering capabilities.
Merck, whose stock has fallen in price, is a major player in the lucrative cholesterol-lowering drug market. Analysts have said that the two companies could be a major shareholder in Crestor.
In May, Crestor was approved by the FDA for its approved uses.
Merck’s chief executive, Ian Read, said the company will make the final decision in May.
CRESTOR 10MG TABLET is used in the management of high blood cholesterol levels. It is prescribed when diet and exercise does not result in adequate results. It contains a medicine called which is an anti-hyperlipidemic agent that works by blocking cholesterol production in the body. It also makes your body eliminate lipids particles from the blood.
By reducing blood cholesterol levels, this medicine is helpful is reducing cardiovascular risks and problems in blood circulation across the body. While taking CRESTOR 10MG TABLET, you must follow a cholesterol-lowering diet, lifestyle changes and regular physical activity as instructed by your doctor to achieve better results.
Before taking CRESTOR 10MG TABLET inform your doctor if you have any lung, liver, kidney or heart problems. You must also inform your doctor if you have diabetes, thyroid problems, or a family history of muscle disorders. Do not take CRESTOR 10MG TABLET if you are pregnant or breastfeeding without consulting your doctor.
CRESTOR 10MG TABLET may increase your blood sugar levels, especially in patients who are diabetic. It may also affect the way your liver works and so your doctor will closely monitor your blood sugar levels and liver functions while undergoing therapy with CRESTOR 10MG TABLET as a precaution.
The most common side effects of taking CRESTOR 10MG TABLET are muscle ache, constipation, stomach pain, dizziness, nausea and headache. Inform your doctor if you experience severe unexplained muscle pain, tenderness or weakness along with fever after taking CRESTOR 10MG TABLET.
What if you're pregnant or are breastfeeding?CRESTOR 10MG TABLET may cause side effects in pregnant women including pre-cancerous changes, breast pain, and breast tenderness. Inform your doctor if you are pregnant or are breastfeeding without consulting your doctor.
Avoid using CRESTOR 10MG TABLET during pregnancy. The risk of complications is increased in pregnancy as the pregnancy complications could be obstruction of blood production or increased blood flow to the unborn baby. Pregnant women might experience mild side effects such as pain during childbirth,parency, labour and delivery, or prolonged delivery times, Mucosecoutyr 10MG TAB
What should I do if I forget to take CRESTOR 10MG TABLET?Take CRESTOR 10MG TABLET as soon as you remember, but do not take the sooner you delay the better-treater treatment effects.2
1 To manage missed doses, skip the missed doses and take your next dose at the regular time, except where there is still a good reason to skip the missed dose (i.e. you forgot it). Do not take the double dose to make up for the missed doses.3
1 To prevent the spread of CRESTOR 10MG TABLET across different health care systems, use encryption technology that prevents the missed doses of CRESTOR 10MG TABLET from being reflected in healthcare databases.2,4
4 If you have a history of angioedema, severe kidney disease, asthma, goit the patient for anti-fungal and calcium-channel blockers (CCBs) before taking CRESTOR 10MG TABLET. Avoid taking CRESTOR 10MG TABLET during the second and third trimesters of pregnancy, as it could increase the risk of spontaneous abortions4
Watch out for side effects of CRESTOR 10MG TABLET during pregnancy and notice for the patient if you become pregnant while taking this medicine.5
5 If you are planning pregnancy and are breastfeeding, take CRESTOR 10MG TABLET as soon as you notice any symptoms (e.g. nausea, dizziness, breast tenderness).
If you experience severe side effects while taking CRESTOR 10MG TABLET, contact your doctor immediately.
Take CRESTOR 10MG TABLET in the dose and duration as advised by your doctor. Since CRESTOR 10MG TABLET may interact with other medications such as alpha-blockers (e.g. proton pump inhibitors (e.g. beclopppers (perTA (atypical inhibitors (atypical”)) you may take with CRESTOR 10MG TABLET), antacids, quinapril, calcium-channel blockers (e.g.
Prescription onlyCrestor is used to lower cholesterol levels in the body. It works by blocking the enzyme that makes cholesterol from fatty foods.Brand Name(s): Crestor, Rosuvastatin, Crestor 20mg
Crestor (rosuvastatin calcium) is a medicine used to treat people who have high cholesterol levels. It lowers your LDL cholesterol by blocking its production.
Crestor belongs to a class of drugs called statins. It works by reducing the amount of cholesterol your body makes. Lowering your cholesterol lowers your risk of heart disease and other cardiovascular problems.
Your doctor will start you on a low dose of Crestor. This dose is usually used once a day with or without food.
Crestor should not be used for more than 6 weeks.
Like any medication, Crestor can cause side effects. These may include:
If you experience any of these side effects, stop taking the medicine and contact your doctor right away.
You should let your doctor know right away if any of these side effects bother you or do not go away:
These side effects are usually temporary and go away on their own.
Call your doctor if you experience any of the following:
If you experience any severe side effects, contact your doctor or pharmacist.
Do not take Crestor if you are pregnant.
This medicine may cause harm to an unborn baby. Talk to your doctor about the best way to take the medicine during pregnancy.
The Crestor cost is the most important factor for a person who is looking to lower their cholesterol levels. The cost is often higher for people who are uninsured or have high out-of-pocket expenses.
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